A Novel Diagnostic Predictive Model for Idiopathic Short Stature in Children.

ABSTRACT:

Objective

Idiopathic short stature (ISS), an endocrine-related disease, is difficult to diagnose. Previous studies have shown that many children with some inflammation-related diseases often have short stature, but whether inflammation is the underlying mechanism of ISS has not been studied. Here, we attempt to explore the role of inflammation in the occurrence and development of ISS and to demonstrate an available clinical diagnostic model of ISS.

Methods

Frozen serum samples were collected from ISS patients (n = 4) and control individuals (n = 4). Isobaric tags for relative and absolute quantitation (iTRAQ) combined with LC-MS/MS analysis were applied to quantitative proteomics analysis. To assess clusters of potentially interacting proteins, functional enrichment (GO and

SUBMITTER: Yuan J 

PROVIDER: S-EPMC8485046 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature