GenoRisk: A polygenic risk score for Alzheimer's disease.

ABSTRACT:

Introduction

Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.

Methods

Case-control data were used to compare the capacity of age, sex, and 58 Alzheimer's disease (AD)-associated single nucleotide polymorphisms (SNPs) to predict AD status using several statistical models. Model performance was assessed with Brier scores and tenfold cross-validation. Genotype and sex × age estimates from the best performing model were combined with age and intercept estimates from the general population to develop a personalized genetic risk score, termed age, and sex-adjusted GenoRisk.

Results

The elastic net model that included age, age x sex interaction, allelic A

SUBMITTER: Dickson SP 

PROVIDER: S-EPMC8485054 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature