Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review.

ABSTRACT: The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-related damage and promoting cell survival. SGs have become important players in human health, in addition to their fundamental role in the stress response. The critical role of SGs in cancer cells in formation, progression, and metastasis makes sense. Recent researchers have found that several SG components play a role in tumorigenesis and cancer metastasis via tumor-associated signaling pathways and other mechanisms. Gene-ontology analysis revealed the role of these protein components in the structure of SGs. Involvement in the translation process, regulation of mRNA stability, and action in both the cytoplasm and nucleus are among the main features of SG proteins. The present scoping review aimed

SUBMITTER: Asadi MR 

PROVIDER: S-EPMC8485071 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature