Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection.

ABSTRACT: Necrotizing soft-tissue infection (NSTI) is a rare, severe, and fast-progressing bacterial infection associated with a high risk of developing sepsis or septic shock. Increasing evidence indicates that oxidative stress is crucial in the development and progression of sepsis, but its role in NSTI specifically has not been investigated. Some patients with NSTI receive hyperbaric oxygen (HBO₂) treatment as the restoration of oxidative stress balance is considered an important mechanism of action, which HBO₂ facilitates. However, a gap in knowledge exists regarding the effect of HBO₂ treatment on oxidative stress in patients with NSTI. In the present observational study, we aimed to investigate HBO₂ treatment effects on known markers of oxidative str

SUBMITTER: Hedetoft M 

PROVIDER: S-EPMC8485130 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature