Brain Activity Fluctuations Propagate as Waves Traversing the Cortical Hierarchy.

ABSTRACT: The brain exhibits highly organized patterns of spontaneous activity as measured by resting-state functional magnetic resonance imaging (fMRI) fluctuations that are being widely used to assess the brain's functional connectivity. Some evidence suggests that spatiotemporally coherent waves are a core feature of spontaneous activity that shapes functional connectivity, although this has been difficult to establish using fMRI given the temporal constraints of the hemodynamic signal. Here, we investigated the structure of spontaneous waves in human fMRI and monkey electrocorticography. In both species, we found clear, repeatable, and directionally constrained activity waves coursed along a spatial axis approximately representing cortical hierarchical organization. These cortical propagations w

SUBMITTER: Gu Y 

PROVIDER: S-EPMC8485153 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature