Association Between Overall Survival and the Tendency for Cancer Programs to Administer Neoadjuvant Chemotherapy for Patients With Advanced Ovarian Cancer.

ABSTRACT:

Importance

Randomized clinical trials have found that, in patients with advanced-stage epithelial ovarian cancer, neoadjuvant chemotherapy has similar long-term survival and improved perioperative outcomes compared with primary cytoreductive surgery. Despite this, considerable controversy remains about the appropriate use of neoadjuvant chemotherapy, and the proportion of patients who receive this treatment varies considerably among cancer programs in the US.

Objective

To evaluate the association between high levels of neoadjuvant chemotherapy administration and overall survival in patients with advanced ovarian cancer.

Design, setting, and participants

This difference-in-differences comparative effectiveness analysis leveraged differential adoption of neoadjuvant che

SUBMITTER: Melamed A 

PROVIDER: S-EPMC8485210 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature