Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer.

ABSTRACT: Histological assessment of prostate cancer is the key diagnostic test and can predict disease outcome. This is however an invasive procedure that carries associated risks, hence non-invasive assays to support the diagnostic pathway are much needed. A key feature of disease progression, and subsequent poor prognosis, is the presence of an altered stroma. Here we explored the utility of prostate stromal cell-derived vesicles as indicators of an altered tumour environment. We compared vesicles from six donor-matched pairs of adjacent-normal versus disease-associated primary stromal cultures. We identified 19 differentially expressed transcripts that discriminate disease from normal stromal extracellular vesicles (EVs). EVs isolated from patient serum were investigated for these putative disea

SUBMITTER: Shephard AP 

PROVIDER: S-EPMC8485336 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature