Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer.

ABSTRACT: Intercellular communication plays an essential role in lung cancer (LC). One of the major players in cell-cell-communication is small extracellular vesicles (sEV). SEV trigger various biological responses by transporting cellular cargo to target cells. One essential sEV component are microRNAs (miRs), whose transport has recently attracted increasing research interest. We report that prostaglandin E₂ (PGE₂ ), a key inflammatory lipid mediator, specifically induces the sorting of miR-574-5p in sEV of A549 and 2106T cells. We found that sEV-derived miR-574-5p activates Toll-like receptors (TLR) 7/8, thereby decreasing PGE₂ -levels. In contrast, intracellular miR-574-5p induces PGE₂ -biosynthesis. Consequently, the combination of intracellular and s

SUBMITTER: Donzelli J 

PROVIDER: S-EPMC8485338 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature