Bicarbonate ion transport by the electrogenic Na⁺ /HCO₃^- cotransporter, NBCe1, is required for normal electrical slow-wave activity in mouse small intestine.

ABSTRACT:

Background

Normal gastrointestinal motility depends on electrical slow-wave activity generated by interstitial cells of Cajal (ICC) in the tunica muscularis of the gastrointestinal tract. A requirement for HCO₃^- in extracellular solutions used to record slow waves indicates a role for HCO₃^- transport in ICC pacemaking. The Slc4a4 gene transcript encoding the electrogenic Na⁺ /HCO₃^- cotransporter, NBCe1, is enriched in mouse small intestinal myenteric region ICC (ICC-MY) that generate slow waves. This study aimed to determine how extracellular HCO₃^- concentrations affect electrical activity in mouse small intestine and to determine the contribution of NBCe1 activity to these effects.

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8485339 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature