A comparative integrated multi-omics analysis identifies CA2 as a novel target for chordoma.

ABSTRACT:

Background

Chordoma is a rare mesenchymal malignancy, with a high recurrence rate and unclear tumorigenic mechanism. Genetic alterations, epigenetic regulators, and chromatin spatial organization play crucial roles in the initiation and progression of chordoma. In the current study, we aim to uncover the novel therapeutical targets for chordoma via using integrated multi-omics analysis.

Methods

The RNA-sequencing (RNA-seq), assay for transposable accessible chromatin by high-throughput sequencing (ATAC-seq), and Hi-C were performed between chordoma and human nucleus pulposus (HNP), along with imageological examination and clinical information. The expressions of identified targets were validated by clinical samples and their functions were further evaluated by cell and anima

SUBMITTER: Meng T 

PROVIDER: S-EPMC8485454 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature