The cytotoxic effect of Baeckea frustescens extracts in eliminating hypoxic breast cancer cells.

ABSTRACT:

Background

Adaptive metabolic response towards a low oxygen environment is essential to maintain rapid tumour proliferation and progression. The vascular network that surrounds the tumour develops an intermittent hypoxic condition and stimulates hypoxia-inducing factors. Baeckea frutescens is used in traditional medicine and known to possess antibacterial and cytoprotective properties. In this study, the cytotoxic effect of B. frutescens leaves and branches extracts against hypoxic human breast cancer (MCF-7) was investigated.

Method

The extracts were prepared using Soxhlet apparatus for ethanol and hexane extracts while the water extracts were freeze-dried. In vitro cytotoxic activities of B. frutescens extracts of various concentrations (20 to 160 μg/mL) at 24, 48, and 72

SUBMITTER: Shahruzaman SH 

PROVIDER: S-EPMC8485548 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature