Mechanisms of instantaneous inactivation of SARS-CoV-2 by silicon nitride bioceramic.

ABSTRACT: The hydrolytic processes occurring at the surface of silicon nitride (Si₃N₄) bioceramic have been indicated as a powerful pathway to instantaneous inactivation of SARS-CoV-2 virus. However, the virus inactivation mechanisms promoted by Si₃N₄ remain yet to be elucidated. In this study, we provide evidence of the instantaneous damage incurred on the SARS-CoV-2 virus upon contact with Si₃N₄. We also emphasize the safety characteristics of Si₃N₄ for mammalian cells. Contact between the virions and micrometric Si₃N₄ particles immediately targeted a variety of viral molecules by inducing post-translational oxidative modifications of S-containing amino acids, nitration of the tyrosine res

SUBMITTER: Pezzotti G 

PROVIDER: S-EPMC8485720 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature