Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait.

ABSTRACT:

Introduction

Freezing of gait (FOG) is a debilitating feature of Parkinson's disease (PD). Evidence suggests patients with FOG have increased cortical control of gait. The supplementary motor area (SMA) may be a key structure due to its connectivity with locomotor and cognitive networks. The objectives of this study were to determine (1) if SMA connectivity is disrupted in patients with FOG and (2) if "inhibitory" repetitive transcranial magnetic stimulation can decrease maladaptive SMA connectivity.

Methods

Two experiments were performed. In experiment 1 resting-state (T2* BOLD imaging) was compared between 38 PD freezers and 17 PD controls. In experiment 2, twenty PD patients with FOG were randomized to either 10 sessions of real or sham rTMS to the SMA (1 Hz, 110% motor t

SUBMITTER: Lench DH 

PROVIDER: S-EPMC8485722 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature