Effectiveness of Medical Treatment of Cushing's Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

The objective of this systematic review was to evaluate the effectiveness and safety of pasireotide, cabergoline, ketoconazole, levoketoconazole, metyrapone, osilodrostat, and temozolomide for the treatment of Cushing's disease (CD).

Methods

The primary outcomes were the proportion of CD control, adverse events (AE), and reduction of urinary free cortisol. Search strategies were applied to Embase, Medline, and CENTRAL. Independent reviewers assessed the study eligibility, extracted data, and evaluated risk of bias. Standardized mean difference was calculated with 95% confidence interval (CI) for continuous data (i.e., pre- and post-intervention). Random meta-analyses for the proportion of CD control and AE were conducted.

Results

Twenty-nine controlle

SUBMITTER: Simoes Correa Galendi J 

PROVIDER: S-EPMC8485729 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature