The Benefits of Intensive Versus Standard Blood Pressure Treatment According to Fine Particulate Matter Air Pollution Exposure: A Post Hoc Analysis of SPRINT.

ABSTRACT: Fine particulate matter <2.5 µm (PM_2.5) air pollution is implicated in global mortality, especially from cardiovascular causes. A large body of evidence suggests a link between PM_2.5 and elevation in blood pressure (BP), with the latter implicated as a potential mediator of cardiovascular events. We sought to determine if the outcomes of intensive BP lowering (systolic BP <120 mm Hg) on cardiovascular events are modified by PM_2.5 exposure in the SPRINT (Systolic BP Intervention Trial). We linked annual PM_2.5 exposure estimates derived from an integrated model to subjects participating in SPRINT. We evaluated the effect of intensive BP lowering by PM_2.5 exposure on the primary outcome in SPRINT using cox-proportional hazard models. A to

SUBMITTER: Al-Kindi SG 

PROVIDER: S-EPMC8485988 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature