A Systematic Review of the Tumor-Infiltrating CD8⁺ T-Cells/PD-L1 Axis in High-Grade Glial Tumors: Toward Personalized Immuno-Oncology.

ABSTRACT: Based on preclinical findings, programmed death-ligand 1 (PD-L1) can substantially attenuate CD8⁺ T-cell-mediated anti-tumoral immune responses. However, clinical studies have reported controversial results regarding the significance of the tumor-infiltrating CD8⁺ T-cells/PD-L1 axis on the clinical picture and the response rate of patients with high-grade glial tumors to anti-cancer therapies. Herein, we conducted a systematic review according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statements to clarify the clinical significance of the tumor-infiltrating CD8⁺ T-cells/PD-L1 axis and elucidate the impact of this axis on the response rate of affected patients to anti-cancer therapies. Indeed, a better understanding o

SUBMITTER: Shadbad MA 

PROVIDER: S-EPMC8486082 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature