SCN2A contributes to oligodendroglia excitability and development in the mammalian brain.

ABSTRACT: Spiking immature oligodendrocytes (OLs), referred to as spiking OLs, express voltage-activated Na⁺ channels (Na_v) and K⁺ (K_v) channels, endowing a subpopulation of OLs with the ability to generate Na_v-driven spikes. In this study, we investigate the molecular profile of spiking OLs, using single-cell transcriptomics paired with whole-cell patch-clamp recordings. SCN2A, which encodes the channel Na_v1.2, is specifically expressed in spiking OLs in the brainstem and cerebellum, both in mice and in Olive baboons. Spiking OLs express lineage markers of OL progenitor cells (OPCs) and pre-myelinating OLs, indicating they belong to a transitional stage during differentiation. Deletion of SCN2A reduces the Na_v current-expr

SUBMITTER: Gould E 

PROVIDER: S-EPMC8486143 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature