Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients.

ABSTRACT:

Objective

Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene-related peptide (CGRP).

Methods

Thirty-six migraine without aura patients were enrolled in a randomized, double-blind, 2-way, crossover, positive-controlled clinical trial study to receive infusion of an amylin analogue pramlintide or human αCGRP on 2 different experimental days. Furthermore, translational studies in cells and mouse models, and rat, mouse and human tissue samples were conducted.

Results

Thirty patients (88

SUBMITTER: Ghanizada H 

PROVIDER: S-EPMC8486152 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature