Determination of brain tumor recurrence using ¹¹ C-methionine positron emission tomography after radiotherapy.

ABSTRACT: We conducted a prospective multicenter trial to compare the usefulness of ¹¹ C-methionine (MET) and ¹⁸ F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for identifying tumor recurrence. Patients with clinically suspected tumor recurrence after radiotherapy underwent both ¹¹ C-MET and ¹⁸ F-FDG PET. When a lesion showed a visually detected uptake of either tracer, it was surgically resected for histopathological analysis. Patients with a lesion negative to both tracers were revaluated by magnetic resonance imaging (MRI) at 3 months after the PET studies. The primary outcome measure was the sensitivity of each tracer in cases with histopathologically confirmed recurrence, as determined by the McNemar test. Sixty-one cases were enrolled,

SUBMITTER: Yamaguchi S 

PROVIDER: S-EPMC8486205 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature