Neural affective mechanisms associated with treatment responsiveness in veterans with PTSD and comorbid alcohol use disorder.

ABSTRACT: Post-traumatic stress disorder (PTSD) is associated with neuro-physiological abnormalities reflecting increased anticipatory anxiety and reactivity to traumatic cues. It remains unclear whether neural mechanisms associated with PTSD treatment responsiveness, i.e. hyperactivation of the affective salience network in the brain, extend to a comorbid PTSD and substance use disorder population. Thirty-one Veterans with PTSD and co-occurring alcohol use disorder (AUD) were randomly assigned to either prolonged exposure or a non-exposure based treatment. They completed an affective anticipation task while undergoing fMRI, immediately prior and after completing treatment. After controlling for type and length of treatment, larger reduction of PTSD symptoms was associated with decreased anticipator

SUBMITTER: Harle KM 

PROVIDER: S-EPMC8486287 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature