The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.

ABSTRACT:

Background

Black men in the United States have markedly higher rates of prostate cancer than the general population. National guidelines for prostate-specific antigen (PSA) screening do not provide clear guidance for this high-risk population. The purpose of this study is to estimate the benefit and harm of intensified PSA screening in Black men.

Methods

Two microsimulation models of prostate cancer calibrated to incidence from the Surveillance, Epidemiology, and End Results program among Black men project the impact of different screening strategies (varying screening intervals, starting and stopping ages, and biopsy utilization following an abnormal PSA) on disease-specific mortality and overdiagnosis. Each strategy induces a mean lead time (MLT) for detected cases. A long

SUBMITTER: Nyame YA 

PROVIDER: S-EPMC8486334 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature