Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort.

ABSTRACT:

Introduction

Prognostic biomarkers and novel therapeutic approaches have been slow to emerge in the treatment of head and neck squamous cell carcinoma (HNSCC). In this study, an HNSCC patient cohort is created and performance of putative prognostic biomarkers investigated in a population-validated setting. The overall goal is to develop a novel way to combine biomarker analyses with population-level clinical data on HNSCC patients and thus to improve the carryover of biomarkers into clinical practice.

Materials and methods

To avoid selection biases in retrospective study design, all HNSCC patients were identified and corresponding clinical data were collected from the Southwest Finland geographical area. A particular emphasis was laid on avoiding potential biases in sample s

SUBMITTER: Routila J 

PROVIDER: S-EPMC8486716 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature