Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.

ABSTRACT: Various behavioral and cognitive states exhibit circadian variations in animals across phyla including Drosophila melanogaster, in which only ~0.1% of the brain's neurons contain circadian clocks. Clock neurons transmit the timing information to a plethora of non-clock neurons via poorly understood mechanisms. Here, we address the molecular underpinning of this phenomenon by profiling circadian gene expression in non-clock neurons that constitute the mushroom body, the center of associative learning and sleep regulation. We show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons, including the Neurofibromin 1 (Nf1) tumor suppressor gene and Pka-C1. Circadian clocks also drive calcium rhythms in mushroom body neurons via NF1-cAMP/PKA-C1 signaling,

SUBMITTER: Machado Almeida P 

PROVIDER: S-EPMC8486785 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature