Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis.

ABSTRACT: The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1 leads to de novo synthesis of arginine, an important amino acid for the growth of intestinal epithelial cells, its upregulation can contribute to epithelial proliferation necessary to be sustained during oncogenic transformation and regeneration. Here we investigated the function of ASS1 in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients. We demonstrate that ASS1 is strongly expressed in the regenerating and A

SUBMITTER: van der Meer JHM 

PROVIDER: S-EPMC8486827 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature