Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC8486850 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Liu Xiuxiu X Pu Wenjuan W He Lingjuan L Li Yan Y Zhao Huan H Li Yi Y Liu Kuo K Huang Xiuzhen X Weng Wendong W Wang Qing-Dong QD Shen Linghong L Zhong Tao T Sun Kun K Ardehali Reza R He Ben B Zhou Bin B
Nature communications 20211001 1
Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Understanding cell-cycle activity of pre-existing cardiomyocytes provides valuable information to heart repair and regeneration. However, the anatomical locations and in situ dynamics of cycling cardiomyocytes remain unclear. Here we develop a genetic approach for a temporally seamless recording of cardiomyocyte-specific cell-cycle activity in vivo. We find that the majority of cycling cardiomyocytes ...[more]