Crossing design shapes patterns of genetic variation in synthetic recombinant populations of Saccharomyces cerevisiae.

ABSTRACT: "Synthetic recombinant" populations have emerged as a useful tool for dissecting the genetics of complex traits. They can be used to derive inbred lines for fine QTL mapping, or the populations themselves can be sampled for experimental evolution. In the latter application, investigators generally value maximizing genetic variation in constructed populations. This is because in evolution experiments initiated from such populations, adaptation is primarily fueled by standing genetic variation. Despite this reality, little has been done to systematically evaluate how different methods of constructing synthetic populations shape initial patterns of variation. Here we seek to address this issue by comparing outcomes in synthetic recombinant Saccharomyces cerevisiae populations created using on

SUBMITTER: Phillips MA 

PROVIDER: S-EPMC8486856 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature