Label-free fiber-optic spherical tip biosensor to enable picomolar-level detection of CD44 protein.

ABSTRACT: Increased level of CD44 protein in serum is observed in several cancers and is associated with tumor burden and metastasis. Current clinically used detection methods of this protein are time-consuming and use labeled reagents for analysis. Therefore exploring new label-free and fast methods for its quantification including its detection in situ is of importance. This study reports the first optical fiber biosensor for CD44 protein detection, based on a spherical fiber optic tip device. The sensor is easily fabricated from an inexpensive material (single-mode fiber widely used in telecommunication) in a fast and robust manner through a CO₂ laser splicer. The fabricated sensor responded to refractive index change with a sensitivity of 95.76 dB/RIU. The spherical tip was further fu

SUBMITTER: Bekmurzayeva A 

PROVIDER: S-EPMC8486867 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature