HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses.

ABSTRACT: Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4⁺ T cells. In conjunction with antibodies recognizing the HIV envelope, NK cells also eliminate HIV-infected targets through antibody-dependent cellular cytotoxicity (ADCC). However, how these NK cell functions impact infected macrophages is less understood. We show that HIV-infected macrophages resist NK cell-mediated killing. Compared with HIV-infected CD4⁺ T cells, initial innate NK cell interactions with HIV-infected macrophages skew the response toward cytokine production, rather than release of cytolytic contents, causing inefficient elimination of infected macrophages. Studies with chimeric antigen receptor (CAR) T cells demonstrate that the viral envelope is equally accessible

SUBMITTER: Clayton KL 

PROVIDER: S-EPMC8486985 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature