Maturation of biomimetic hydroxyapatite in physiological fluids: a physicochemical and proteomic study.

ABSTRACT: Biomimetic calcium-deficient hydroxyapatite (CDHA) as a bioactive material exhibits exceptional intrinsic osteoinductive and osteogenic properties because of its nanostructure and composition, which promote a favorable microenvironment. Its high reactivity has been hypothesized to play a relevant role in the in vivo performance, mediated by the interaction with the biological fluids, which is amplified by its high specific surface area. Paradoxically, this high reactivity is also behind the in vitro cytotoxicity of this material, especially pronounced in static conditions. The present work explores the structural and physicochemical changes that CDHA undergoes in contact with physiological fluids and to investigate its interaction with proteins. Calcium-deficient hydroxyapati

SUBMITTER: Konka J 

PROVIDER: S-EPMC8487082 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature