Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients.

ABSTRACT:

Introduction

Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes.

Methods

In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including 160 asymptomatic, 250 mild/moderate, and 90 severe/critical cases. The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR).

Results

Interestingly, s

SUBMITTER: Abdollahzadeh R 

PROVIDER: S-EPMC8487094 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature