Cohort profile: Prematurity Immunology in Mothers living with HIV and their infants Study (PIMS).

ABSTRACT:

Purpose

Prematurity Immunology in Mothers living with HIV and their infants Study (PIMS) is a prospective cohort study in South Africa investigating the association between antiretroviral therapy (ART) use, preterm delivery (PTD) and small-for-gestational age (SGA) live births. PIMS main hypotheses are that ART initiation in pregnancy and ART-induced hypertension are associated with PTD and SGA respectively and that reconstitution of cellular immune responses in women on ART from before pregnancy results in increases in PTD of GA infants.

Participants

Pregnant women (n=3972) aged ≥18 years regardless of HIV status recruited from 2015 to 2016 into the overall PIMS cohort (2517 HIV-negative, 1455 living with HIV). A nested cohort contained 551 women living with HIV who were ≤2

SUBMITTER: Malaba TR 

PROVIDER: S-EPMC8487191 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature