Integrative analysis of miRNA-mRNA network in idiopathic membranous nephropathy by bioinformatics analysis.

ABSTRACT:

Background

Currently, several specific antigens, M-type receptor for secretory phospholipase A2(PLA2R1), thrombospondin type-1 domain-containing 7A(THSD7A), and neural epidermal growth factor-like 1 protein (NELL-1), are discovered associated with the onset of idiopathic membranous nephropathy (IMN). But the pathomechanisms of IMN still need to be further claried. Understanding the mechanisms of IMN is required to improve its diagnosis and treatment.

Methods

In this study, we constructed miRNA regulatory networks to investigate IMN development. Moreover, miRNAs and mRNAs that were differentially expressed between Idiopathic Membranous Nephropathy (IMN) patients and normal controls were examined using the GSE115857 dataset and our previous sequence study. DE miRNA target gene

SUBMITTER: He W 

PROVIDER: S-EPMC8487241 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature