A systematic review and network meta-analysis of the safety of early interventional treatments in rheumatoid arthritis.

ABSTRACT:

Objectives

To evaluate the safety of treatment strategies in patients with early RA.

Methods

Systematic searches of MEDLINE, EMBASE and PubMed were conducted up to September 2020. Double-blind randomized controlled trials (RCTs) of licensed treatments conducted on completely naïve or MTX-naïve RA patients were included. Long-term extension studies, post-hoc and pooled analyses and RCTs with no comparator arm were excluded. Serious adverse events, serious infections and non-serious adverse events were extracted from all RCTs, and event rates in intervention and comparator arms were compared using meta-analysis and network meta-analysis (NMA).

Results

From an initial search of 3423 studies, 20 were included, involving 9202 patients. From the meta-analysis, the pooled in

SUBMITTER: Adas MA 

PROVIDER: S-EPMC8487311 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature