A distinguishing profile of chemokines, cytokines and biomarkers in the saliva of children with Sjogren's syndrome.

ABSTRACT:

Objective

SS is an autoimmune disease most commonly diagnosed in adults but can occur in children. Our objective was to assess the presence of chemokines, cytokines and biomarkers (CCBMs) in saliva from these children that were associated with lymphocyte and mononuclear cell functions.

Methods

Saliva was collected from 11 children diagnosed with SS prior to age 18 years and 16 normal healthy children. A total of 105 CCBMs were detected in multiplex microparticle-based immunoassays. ANOVA and t test (0.05 level) were used to detect differences. Ingenuity Pathway Analysis (IPA) was used to assess whether elevated CCBMs were in annotations associated with immune system diseases and select leukocyte activities and functions. Machine learning methods were used to evaluate the pre

SUBMITTER: Gomez Hernandez MP 

PROVIDER: S-EPMC8487313 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature