Striatal Low-Threshold Spiking Interneurons Regulate Goal-Directed Learning.

ABSTRACT: The dorsomedial striatum (DMS) is critically involved in motor control and reward processing, but the specific neural circuit mediators are poorly understood. Recent evidence highlights the extensive connectivity of low-threshold spiking interneurons (LTSIs) within local striatal circuitry; however, the in vivo function of LTSIs remains largely unexplored. We employed fiber photometry to assess LTSI calcium activity in a range of DMS-mediated behaviors, uncovering specific reward-related activity that is down-modulated during goal-directed learning. Using two mechanistically distinct manipulations, we demonstrated that this down-modulation of LTSI activity is critical for acquisition of novel contingencies, but not for their modification. In contrast, continued LTSI activation slowed instr

SUBMITTER: Holly EN 

PROVIDER: S-EPMC8487455 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature