Intra-population differences of apolipoproteins in the aqueous humor.

ABSTRACT:

Background

Evidence suggests that proteins related to lipid metabolism, such as apolipoproteins, play an important role in the maintenance of normal vision. While several members of the apolipoprotein family are abundant in human aqueous humor (AH), their study remains difficult due to the AH's small volume, low protein concentration, and the invasive nature of sample collection. In this study, we report the use of Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) to discover associations between AH apolipoproteins and race, gender, and ocular structure in patients with and without primary open angle glaucoma (POAG).

Methods

AH samples were collected from 231 patients undergoing phacoemulsification or glaucoma incisional surgery at the Medical College of Georgia, Aug

SUBMITTER: Patel PA 

PROVIDER: S-EPMC8487476 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature