Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.

ABSTRACT:

Background

Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia.

Methods

We performed an open, multicenter trial in which infants with a birth weight of 1000 g or less and a gestational age between 22 weeks 0 days and 28 weeks 6 days were randomly assigned within 48 hours after delivery to receive red-cell transfusions at higher or lower hemoglobin thresholds until 36 weeks of postmenstrual age or discharge, whichever occurred first. The primary outcome was a composite of death or neurodevelopmental impairment (cognitive delay, cerebral palsy, or hearing or vision loss) at 22 to 26 months of age, corrected for prematurity.

Results

A total of 1824 inf

SUBMITTER: Kirpalani H 

PROVIDER: S-EPMC8487591 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature