Utility of a Computerized ICD-10 Algorithm to Identify Idiosyncratic Drug-Induced Liver Injury Cases in the Electronic Medical Record.

ABSTRACT:

Introduction

Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver injury that is difficult to diagnose and identify in the electronic medical record (EMR).

Objective

Our objective was to develop a computerized algorithm that can reliably identify DILI cases from the EMR.

Methods

The EMR was searched for all encounters with an International Classification of Diseases, Tenth Revision (ICD-10) T code for drug toxicity and a K-71 code for toxic liver injury between 1 October 2015 and 30 September 2018. Clinically significant liver injury was defined using predetermined laboratory values. An expert opinion causality score (1-3 = probable DILI, 4/5 = non-DILI), Roussel Uclaf Causality Assessment Method (RUCAM) score, and severity score was assigned

SUBMITTER: Yeboah-Korang A 

PROVIDER: S-EPMC8487619 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature