Epilepsy Is Heterogeneous in Early-Life Tuberous Sclerosis Complex.

ABSTRACT:

Background

Epilepsy in tuberous sclerosis complex (TSC) typically presents with early onset, multiple seizure types, and intractability. However, variability is observed among individuals. Here, detailed individual data on seizure characteristics collected prospectively during early life were used to define epilepsy profiles in this population.

Methods

Children aged zero to 36 months were followed longitudinally. Caregivers kept daily seizure diaries, including onset and daily counts for each seizure type. Patients with >70% seizure diary completion and >365 diary days were included. Developmental outcomes at 36 months were compared between subgroups.

Results

Epilepsy was seen in 124 of 156 (79%) participants. Seizure onset occurred from zero to 29.5 months; 93% had o

SUBMITTER: Ihnen SKZ 

PROVIDER: S-EPMC8487620 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature