PheWAS-ME: a web-app for interactive exploration of multimorbidity patterns in PheWAS.

ABSTRACT:

Summary

Electronic health records (EHRs) linked with a DNA biobank provide unprecedented opportunities for biomedical research in precision medicine. The Phenome-wide association study (PheWAS) is a widely used technique for the evaluation of relationships between genetic variants and a large collection of clinical phenotypes recorded in EHRs. PheWAS analyses are typically presented as static tables and charts of summary statistics obtained from statistical tests of association between a genetic variant and individual phenotypes. Comorbidities are common and typically lead to complex, multivariate gene-disease association signals that are challenging to interpret. Discovering and interrogating multimorbidity patterns and their influence in PheWAS is difficult and time-consuming. We

SUBMITTER: Strayer N 

PROVIDER: S-EPMC8487628 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature