Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors.

ABSTRACT: Strong epidemiological evidence demonstrates an association between chronic arsenic exposure and anemia. We recently found that As⁺³ impairs erythropoiesis by disrupting the function of GATA-1; however the downstream pathways impacted by the loss of GATA-1 function have not been evaluated. Additionally, our previous findings indicate that the predominant arsenical in the bone marrow of mice exposed to As⁺³ in their drinking water for 30 days was MMA⁺³, but the impacts of this arsenical on erythorpoisis also remain largely unknown. The goal of this study was to address these critical knowledge gaps by evaluating the comparative effects of arsenite (As⁺³) and the As⁺³ metabolite, monomethyarsonous acid (MMA⁺³) on two critical

SUBMITTER: Medina S 

PROVIDER: S-EPMC8487637 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature