Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease.

ABSTRACT: Venous disease is a term that broadly covers both venous thromboembolic disease and chronic venous disease. The basic pathophysiology of venous thromboembolism and chronic venous disease differ as venous thromboembolism results from an imbalance of hemostasis and thrombosis while chronic venous disease occurs in the setting of tissue damage because of prolonged venous hypertension. Both diseases are common and account for significant mortality and morbidity, respectively, and collectively make up a large health care burden. Despite both diseases having well-characterized environmental components, it has been known for decades that family history is an important risk factor, implicating a genetic element to a patient's risk. Our understanding of the pathogenesis of these diseases has greatl

SUBMITTER: Baylis RA 

PROVIDER: S-EPMC8487638 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature