Dataset Information

Association of oral contraceptives and tubal ligation with risk of early natural menopause.

ABSTRACT:

Study question

What is the association of oral contraceptives (OCs) and tubal ligation (TL) with early natural menopause?

Summary answer

We did not observe an association of OC use with risk of early natural menopause; however, TL was associated with a modestly higher risk.

What is known already

OCs manipulate hormone levels, prevent ovulation, and may modify the rate of follicular atresia, while TL may disrupt the blood supply to the ovaries. These mechanisms may be associated with risk of early menopause, a condition associated with increased risk of cardiovascular disease and other adverse health outcomes.