A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

ABSTRACT:

Study question

To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary answer

In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2.5 or NO2, were associated with increased risk of UL.

What is known already

UL are benign tumors of the myometrium that are the leading cause of gynecologic inpatient care among reproductive-aged women. Black women are clinically diagnosed at two to three times the rate of white women and tend to exhibit earlier onset and more severe disease. Two epidemiologic studies have found positive associations between air pollution exposure and UL ri

SUBMITTER: Wesselink AK 

PROVIDER: S-EPMC8487660 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature