Prospective Clinical, Virologic, and Immunologic Assessment of COVID-19 in Transplant Recipients.

ABSTRACT:

Background

Several studies have described the clinical features of COVID-19 in solid-organ transplant recipients. However, many have been retrospective or limited to more severe cases (hospitalized) and have not routinely included serial virological sampling (especially in outpatients) and immunologic assessment.

Methods

Transplant patients diagnosed with COVID-19 based on a respiratory sample PCR were prospectively followed up to 90 d. Patients provided consent for convalescent serum samples and serial nasopharyngeal swabs for SARS-CoV-2 antibody (antinucleoprotein and anti-RBD) and viral load, respectively.

Results

In the 161 SOT recipients diagnosed with COVID-19, the spectrum of disease ranged from asymptomatic infection (4.3%) to hospitalization (60.6%), suppleme

SUBMITTER: Marinelli T 

PROVIDER: S-EPMC8487707 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature