Gastric Cancer Risk of Intestinal Metaplasia Subtypes: A Systematic Review and Meta-Analysis of Cohort Studies.

ABSTRACT:

Introduction

Intestinal metaplasia (IM) is an independent risk factor for gastric cancer (GC). However, the subtypes of IM as a risk factor for GC remain controversial. We performed a systematic review and meta-analysis to evaluate the relationship between IM subtypes and GC risk.

Methods

Systematic searches were conducted in PubMed, EMBASE, and the Cochrane Library for published cohort studies of patients with complete IM (type I) or incomplete IM (type II or type III) from inception to May 15, 2021. We extracted relevant data and calculated pooled risk ratios (RRs) and 95% confidence intervals (CIs) comparing the GC risk with IM subtypes.

Results

Twelve cohort studies comprising 6,498 individuals were included in the study. Compared with complete IM, the pooled rela

SUBMITTER: Du S 

PROVIDER: S-EPMC8487777 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature