Genetic and immune characteristics of multiple primary lung cancers and lung metastases.

ABSTRACT:

Background

To explore the genetic and immunophenotyping heterogeneities between patients with intrapulmonary metastasis (IPM) or multiple primary lung cancer (MPLC).

Methods

Whole exome sequencing (WES) and transcriptome sequencing (RNA-seq) were performed on the tissue and blood samples of IPM and MPLC patients to comprehensively analyze the clonal evolution, molecular typing and immunophenotyping.

Results

There was no significant difference in genetic mutation, tumor mutational burden (TMB) value and mutant allele tumor heterogeneity (MATH) value between IPM and MPLC patients. Notably, the loss of heterozygosity (LOH) of human leukocyte antigen (HLA) appeared in all IPM patients, while there was also no significant difference between the two groups. In addition, exp

SUBMITTER: Yang R 

PROVIDER: S-EPMC8487821 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature