Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.

ABSTRACT:

Objectives

Observational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses.

Methods

We carried out analyses using summary statistics data for genetic variants reported from a GWAS of insomnia (N = up to 1,331,010 individuals) and from a GWAS of PUD (N = up to 456,327 individuals). Three Mendelian randomization approaches were used to explore whether insomnia might play a causal role in PUD, and pathway and functional enrichment analyses were conducted to anticipate the underlying mechanisms.

Results

Conventional Mendelian randomization analysis showed clear causality between insomnia and PUD; 1 SD increased

SUBMITTER: Zha LF 

PROVIDER: S-EPMC8487841 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature