Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices.

ABSTRACT: In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS spectra of TCS as free phenol and as derivatized species are characterized; thereafter, the effects of several instrumental variables in the detectability of TCS (i.e., temperature, solvent, and compound holder) are discussed. Under final selected conditions, TCS was determined from its [M-H]^- ions, without need of derivatization, attaining an instrumental limit of quantification of 5 ng mL^-1, with a linear response range up to 1000 ng mL^-1. Complex matrices, su

SUBMITTER: Cobo-Golpe M 

PROVIDER: S-EPMC8487875 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature