Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking.

ABSTRACT: Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel stability. Defects in vascular Col IV deposition are the basis of heritable disorders, such as small vessel disease, marked by cerebral hemorrhage and drastically shorten lifespan. To date, little is known about how endothelial cells regulate the intracellular transport and selective secretion of Col IV in response to angiogenic cues, leaving a void in our understanding of this critical process. Our aim was to identify trafficking pathways that regulate Col IV deposition during angiogenic blood vessel development. We have identified the GTPase Rab10 as a major regulator of Col IV vesicular trafficking during vascular development using both in vitro ima

SUBMITTER: Gross SJ 

PROVIDER: S-EPMC8487879 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature